Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

AN Archambault; YR Su; J Jeon; M Thomas; Y Lin; DV Conti; AK Win; LC Sakoda; I Lansdorp-Vogelaar; EFP Peterse; AG Zauber; D Duggan; AN Holowatyj; JR Huyghe; H Brenner; M Cotterchio; S Bézieau; SL Schmit; CK Edlund; MC Southey; RJ MacInnis; PT Campbell; J Chang-Claude; ML Slattery; AT Chan; AD Joshi; M Song; Y Cao; MO Woods; E White; SJ Weinstein; CM Ulrich; M Hoffmeister; SA Bien; TA Harrison; J Hampe; CI Li; C Schafmayer; K Offit; PD Pharoah; V Moreno; A Lindblom; A Wolk; AH Wu; L Li; MJ Gunter; A Gsur; TO Keku; R Pearlman; DT Bishop; S Castellví-Bel; L Moreira; P Vodicka; E Kampman; GG Giles; D Albanes; JA Baron; SI Berndt; S Brezina; S Buch; DD Buchanan; A Trichopoulou; G Severi; MD Chirlaque; MJ Sánchez; D Palli; T Kühn; N Murphy; AJ Cross; AN Burnett-Hartman; SJ Chanock; A de la Chapelle; DF Easton; F Elliott; DR English; EJM Feskens; LM FitzGerald; PJ Goodman; JL Hopper; TJ Hudson; DJ Hunter; EJ Jacobs; CE Joshu; S Küry; SD Markowitz; RL Milne; EA Platz; G Rennert; HS Rennert; FR Schumacher; RS Sandler; D Seminara; CM Tangen; SN Thibodeau; AE Toland; FJB van Duijnhoven; K Visvanathan; L Vodickova; JD Potter; S Männistö

Journal article

Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

AN Archambault, YR Su, J Jeon, M Thomas, Y Lin, DV Conti, AK Win, LC Sakoda, I Lansdorp-Vogelaar, EFP Peterse, AG Zauber, D Duggan, AN Holowatyj, JR Huyghe, H Brenner, M Cotterchio, S Bézieau, SL Schmit, CK Edlund, MC Southey Show all

Gastroenterology | Published : 2020

DOI: 10.1053/j.gastro.2019.12.012

Abstract

Background & Aims: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. Methods: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 201..

View full abstract